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KMID : 1039120240130010068
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Clinical and Experimental Vaccine Research
2024 Volume.13 No. 1 p.68 ~ p.71
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Acute interstitial nephritis with acute kidney injury after COVID-19 vaccination: a case report
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Lim Ji-Min
Paek Jin-Hyuk
Shin Hyeong-Chan
Park Woo-Yeong
Jin Kyu-Bok
Choe Mi-Sun
Han Seung-Yeup
Kim Yae-Rim
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Abstract
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In the context of the massive spread of coronavirus disease 2019 (COVID-19), the development of a COVID-19 vaccine is urgently needed. The Pfizer-BioNTech COVID-19 vaccine has been widely applied across global populations. Herein, we report a case of acute interstitial nephritis with acute kidney injury in a young healthy subject after administration of the COVID-19 vaccine. A 20-year-old man was admitted with abdominal discomfort and nausea. He had received the Pfizer-BioNTech COVID-19 vaccine 6 days before. At 9 days after vaccination, his kidney function was decreased, with serum creatinine levels of 1.8 mg/dL. Even with supportive care with hydration, his kidney function worsened, and he underwent a kidney biopsy. The pathology findings revealed diffuse interstitial infiltration of inflammatory cells, predominantly comprising lymphocytes, with preservation of the glomerulus. No abnormal findings were noted by immunofluorescence or electron microscopy. Based on a diagnosis of drug-related acute interstitial nephritis, we treated the patient with high-dose prednisolone. After administration of prednisolone, kidney function slowly improved. A close linkage between COVID-19 vaccination and acute interstitial nephritis should be considered in the clinic, despite the low incidence.
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KEYWORD
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Interstitial nephritis, Acute kidney injury, COVID-19, Case report, Vaccination
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